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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Establishment of an orthotopic patient-derived xenograft mouse model using uveal melanoma hepatic metastasis

Fig. 1

a Schematic overview of liver and subcutaneous tumor implantation by needle injection using established cell lines. For mice injected with tumor suspensions into the liver, tumor volume was measured at sacrifice. Liver UM001 tumor-bearing mice were sacrificed at 8 weeks and UM004 tumor-bearing mice were sacrificed at 4 weeks post-injection. For mice injected with tumor suspensions at the subcutaneous site, tumor volume was measured three times (4, 8, and 12 weeks) before the mice were sacrificed at 12 weeks post-injection. bp Macroscopic, histopathological, and radiological features of liver and subcutaneous tumors generated with established cell lines. b, j Laparotomy image. c, h, k, p Macroscopic findings for resected tumors. d, l Cut surface of the tumor. e, m Sagittal imaging using CT, black arrows indicate tumors. f, n H&E staining, ×10, Scale bar 1 mm. g, o Macroscopic findings for subcutaneously injected sites. i H&E staining, ×400, Scale bar 50 µm. SC subcutaneous site

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