Table 3 Cobimetinib dose modification after the first event of serous retinopathy in the cobimetinib plus vemurafenib arm
Action taken with cobimetinib | All patients with serous retinopathy events (n = 63) | Patients with grade 1 events (n = 36) | Patients with grade 2 events (n = 20) | Patients with grade 3 events (n = 6) | Patients with grade 4 events (n = 1) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
All | Resolved | All | Resolved | All | Resolved | All | Resolved | All | Resolved | |
Dose not changed, n | 30 | 12 | 26 | 10 | 3 | 1 | 1 | 1 | 0 | 0 |
Dose reduced, n | 18 | 16 | 4 | 3 | 13 | 12 | 1 | 1 | 0 | 0 |
Drug interrupted, n | 10 | 5 | 5 | 3 | 2 | 0 | 3 | 2 | 0 | 0 |
Drug withdrawn, n | 4 | 1 | 0 | 0 | 2 | 1 | 1a | 0 | 1a | 0 |
Unknown, n | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |