Fig. 2

Cardiac [⁶⁸Ga]NODAGA-RGD and [¹⁵O]water in vivo PET analyses. a and b demonstrate polar maps of MBF measured by [¹⁵O]water PET at rest and during adenosine stress, respectively. c and d show polar maps of [⁶⁸Ga]NODAGA-RGD uptake. Note the presence of increased [⁶⁸Ga]NODAGA-RGD uptake in c co-localizing with an area of reduced myocardial perfusion (asterisk in a, b) as compared with the remote area (arrowhead in a, b). Distribution of [⁶⁸Ga]NODAGA-RGD is homogenous in the left ventricle of sham operated pig (d)