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Table 1 Pre-clinical antibody gene transfer studies ranked according to expression platform and indication

From: State of play and clinical prospects of antibody gene transfer

Expression platform Disease indication References
Viral vector
 AdV Cancer [31, 32, 59]
Infectious diseases Clostridium botulinum [45]
Clostridium difficile [43]
Influenza [55]
Respiratory syncytial virus [57]
Yersinia pestis [38, 166]
West Nile virus [167]
Other Pulmonary edema [56]
 rAAV Cancer [71, 83, 84, 168,169,170,171,172]
CNS Alzheimer’s disease [35, 37, 73,74,75,76,77,78, 173, 174]
Huntington disease [76, 173]
Prion disease [33, 34, 175]
Infectious diseases Anthrax [42, 82]
Ebola [72]
Hepatitis C [176]
HIV (in mouse) [70, 177,178,179]
SIV (in rhesus macaque) [23, 24, 90,91,92]
Influenza [55, 79, 80, 180]
Malaria [181]
Respiratory syncytial virus [57]
Other Addiction [182, 183]
Gelsolin amyloidosis  [27]
Contraception [184]
Macular degeneration [81]
 Oncolytic virus Cancer [30, 36, 39, 99,100,101, 103, 104, 106,107,108,109]
Naked DNA
 pDNA Auto-immune disease [131]
Cancer [141, 185, 186]
Infectious diseases Chikungunya virus [29]
Dengue virus [136]
Ebola [137, 138, 187]
Hepatitis B [133]
HIV [28]
Influenza [134]
Pneumonia [25]
 mcDNA Cancer [26]
Inflammatory diseases Arthritis [143]
Skin allograft survival [144]
RNA
 mRNA-LNP Cancer [44]
Infectious diseases Clostridium botulinum [44]
HIV [150]
Influenza B [44]
Rabies [44]
  1. AdV adenovirus, CNS central nervous system, rAAV recombinant adeno-associated virus, pDNA plasmid DNA, mcDNA minicircle DNA, HIV human immunodeficiency virus, SIV simian immunodeficiency virus, mRNA-LNP messenger RNA encapsulated in lipid nanoparticles