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Table 1 Pre-clinical antibody gene transfer studies ranked according to expression platform and indication

From: State of play and clinical prospects of antibody gene transfer

Expression platform

Disease indication

References

Viral vector

 AdV

Cancer

[31, 32, 59]

Infectious diseases

Clostridium botulinum

[45]

Clostridium difficile

[43]

Influenza

[55]

Respiratory syncytial virus

[57]

Yersinia pestis

[38, 166]

West Nile virus

[167]

Other

Pulmonary edema

[56]

 rAAV

Cancer

[71, 83, 84, 168,169,170,171,172]

CNS

Alzheimer’s disease

[35, 37, 73,74,75,76,77,78, 173, 174]

Huntington disease

[76, 173]

Prion disease

[33, 34, 175]

Infectious diseases

Anthrax

[42, 82]

Ebola

[72]

Hepatitis C

[176]

HIV (in mouse)

[70, 177,178,179]

SIV (in rhesus macaque)

[23, 24, 90,91,92]

Influenza

[55, 79, 80, 180]

Malaria

[181]

Respiratory syncytial virus

[57]

Other

Addiction

[182, 183]

Gelsolin amyloidosis 

[27]

Contraception

[184]

Macular degeneration

[81]

 Oncolytic virus

Cancer

[30, 36, 39, 99,100,101, 103, 104, 106,107,108,109]

Naked DNA

 pDNA

Auto-immune disease

[131]

Cancer

[141, 185, 186]

Infectious diseases

Chikungunya virus

[29]

Dengue virus

[136]

Ebola

[137, 138, 187]

Hepatitis B

[133]

HIV

[28]

Influenza

[134]

Pneumonia

[25]

 mcDNA

Cancer

[26]

Inflammatory diseases

Arthritis

[143]

Skin allograft survival

[144]

RNA

 mRNA-LNP

Cancer

[44]

Infectious diseases

Clostridium botulinum

[44]

HIV

[150]

Influenza B

[44]

Rabies

[44]

  1. AdV adenovirus, CNS central nervous system, rAAV recombinant adeno-associated virus, pDNA plasmid DNA, mcDNA minicircle DNA, HIV human immunodeficiency virus, SIV simian immunodeficiency virus, mRNA-LNP messenger RNA encapsulated in lipid nanoparticles