Fig. 5

Analysis of OCs within MRONJ (BP) specimens. a Shows three different visual fields of the same MRONJ (BP) histological section [(anti-)DC-STAMP staining]. Nuclear counterstaining was performed. Arrowheads mark a bundle of potential osteoclastic precursors with a high expression of DC-STAMP. The arrow marks an osteoclast with intermediate DC-STAMP expression. Double arrows tag giant hypernucleated osteoclasts with no DC-STAMP expression. Below the visual fields, an illustration model depicts the gradual loss of DC-STAMP receptors during osteoclastogenesis. b, c Show the comparison between DC-STAMP+ osteoclasts and average osteoclasts (H&E). b Illustrates differences in osteoclast diameter. b Visualizes differences in number of nuclei per osteoclast