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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Osteoclast profile of medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis

Fig. 2

Quantitative and morphological analysis of osteoclasts (H&E): MRONJ (BP) vs. OM vs. ORN vs. control. a Depicts a giant hypernucleated osteoclast (arrowhead) within a MRONJ (BP) histological section. Note the pyknotic nuclei, the round shape, the detachment from the bone surface and the lack of ruffled borders. b Illustrates the number of osteoclasts per ROI. c, d Illustrate morphological differences in osteoclasts. * and ° mark statistical outliers. For detailed data see Table 2. MRONJ (BP) medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy, OC osteoclasts, OM osteomyelitis, ORN osteoradionecrosis, DC-STAMP dendritic cell-specific transmembrane protein, TRAP tartrate-resistant acid phosphatase

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