Fig. 3

Fold-change of plasma levels of biomarkers in dengue patients without warning signs, without warning signs and severe dengue over the different phases of illness. A Wilcoxon matched-pairs test was used to assess the changes of biomarkers levels from febrile phase to defervescence phase. Fold-change of plasma marker was defined as the median level of each biomarkers at defervescence phase was divided by their respective level at febrile phase. The fold-change was then reflected by the colour scale in the heatmap in P value less than 0.05 (significant), where *<0.05, **<0.01, ***<0.001, ****<0.0001