Fig. 1
From: Non-caloric sweetener provides magnetic resonance imaging contrast for cancer detection
CEST effect from sucralose. a Chemical structure of sucralose shows the exchangeable –OH groups. b High resolution NMR spectrum of 200 mM sucralose solution in PBS shows two peaks from exchangeable hydroxyl protons (–OH) respectively at 1.0 and 1.5 ppm at 5 °C temperature. The peaks broadened with increase in temperature and were completely broadened at 37 °C. c, d Z-spectra and MTRasym curves from 10 mM of sucralose (pH 7, 37 °C) show broad resonance (0–3 ppm), which peaked around 1 ppm. e The dependence of sucCEST contrast on saturation power and duration. The optimal B1 for the sucCEST contrast in the phantom was 7 µT. f The graph shows sucCEST contrast from 10 mM sucralose phantom at different saturation duration for a fixed B1 power (7 µT)