Fig. 2
From: The spleen in liver cirrhosis: revisiting an old enemy with novel targets
Diagram of the liver and spleen crosstalk pathways during liver cirrhosis. During liver cirrhosis progression, spleen-derived immune cells and cytokines may travel into the injured liver via portal blood flow. At the same time, liver cirrhosis also contributes to portal hypertension, which leads to the congestion of the portal system and may give rise to splenomegaly and hypersplenism. The cirrhotic liver may also release chemokines, DAMPs like HMGB1, or exosomes into the circulation, which trigger the activation and/or migration of splenocytes