Differential expression of microRNAs following cardiopulmonary bypass in children with congenital heart diseases

Table 3 The KEGG pathways significantly enriched for target genes of deregulated miRNAs in the atrial myocardial tissue from patients with CHD after CPB (n = 3) compared to before CPB (n = 3) ( P value < 0.05)

Mode of interaction	KEGG pathway	P-value	No. genes	No. miRNAs
Signaling transduction	Hippo signaling pathway	1.11E + 05	114	70
	Phosphatidylinositol signaling system	1.23E + 06	66	63
	TGF-beta signaling pathway	3.29E + 06	64	53
	cGMP-PKG signaling pathway	3.29E + 06	128	74
	FoxO signaling pathway	0.001	98	72
	ErbB signaling pathway	0.0027	67	62
	MAPK signaling pathway	0.003	179	77
	Ras signaling pathway	0.0035	155	76
	Sphingolipid signaling pathway	0.0145	85	64
	Calcium signaling pathway	0.0174	124	71
	AMPK signaling pathway	0.0189	86	67
	cAMP signaling pathway	0.019	137	71
	TNF signaling pathway	0.0229	76	63
	Rap1 signaling pathway	0.0243	143	70
Cardiovascular diseases and Circulatory system	Adrenergic signaling in cardiomyocytes	1.20E + 06	112	71
	Dilated cardiomyopathy	0.0154	65	57
	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	0.0174	53	54
	Vascular smooth muscle contraction	0.0196	83	65
Cellular community	Adherens junction	3.20E − 03	56	58
	Focal adhesion	0.0044	146	74
	Gap junction	0.0106	65	61
	Cell adhesion molecules (CAMs)	0.0248	98	68

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