Skip to main content

Table 3 The KEGG pathways significantly enriched for target genes of deregulated miRNAs in the atrial myocardial tissue from patients with CHD after CPB (n = 3) compared to before CPB (n = 3) ( P value < 0.05)

From: Differential expression of microRNAs following cardiopulmonary bypass in children with congenital heart diseases

Mode of interaction KEGG pathway P-value No. genes No. miRNAs
Signaling transduction Hippo signaling pathway 1.11E + 05 114 70
Phosphatidylinositol signaling system 1.23E + 06 66 63
TGF-beta signaling pathway 3.29E + 06 64 53
cGMP-PKG signaling pathway 3.29E + 06 128 74
FoxO signaling pathway 0.001 98 72
ErbB signaling pathway 0.0027 67 62
MAPK signaling pathway 0.003 179 77
Ras signaling pathway 0.0035 155 76
Sphingolipid signaling pathway 0.0145 85 64
Calcium signaling pathway 0.0174 124 71
AMPK signaling pathway 0.0189 86 67
cAMP signaling pathway 0.019 137 71
TNF signaling pathway 0.0229 76 63
Rap1 signaling pathway 0.0243 143 70
Cardiovascular diseases and Circulatory system Adrenergic signaling in cardiomyocytes 1.20E + 06 112 71
Dilated cardiomyopathy 0.0154 65 57
Arrhythmogenic right ventricular cardiomyopathy (ARVC) 0.0174 53 54
Vascular smooth muscle contraction 0.0196 83 65
Cellular community Adherens junction 3.20E − 03 56 58
Focal adhesion 0.0044 146 74
Gap junction 0.0106 65 61
Cell adhesion molecules (CAMs) 0.0248 98 68