Table 3 Functional pathways identified in mRNA targets for miRNAs
From: Bovis Bacillus Calmette–Guerin (BCG) infection induces exosomal miRNA release by human macrophages
p value | Number of miRNAs in each pathway | |
|---|---|---|
Pathways in bacterial digestion | ||
Proteasome | 0.0139 | 3 |
Ubiquitin-mediated proteolysis | 0.0057 | 7 |
Pathways in infection process | ||
Bacterial invasion of epithelial cells | 0.0310 | 7 |
Endocytosis | 0.0337 | 8 |
ECM-receptor interaction | 0.00153 | 4 |
Adherents junction | 0.00730 | 4 |
Inositol phosphate metabolism | 0.00201 | 4 |
Pathways in fatty acid metabolism | ||
Fatty acid biosynthesis | 0.00000000684 | 3 |
Fatty acid metabolism | 0.00000154 | 5 |
Fatty acid elongation | 0.000738 | 3 |
Steroid biosynthesis | 0.00631 | 3 |
2-Oxocarboxylic acid metabolism | 0.0165 | 3 |
Pathways in amino acids metabolism | ||
Phenylalanine, tyrosine and tryptophan biosynthesis | 0.000713 | 3 |
Valine, leucine and isoleucine degradation | 0.0310 | 6 |
Lysine degradation | 0.0421 | 6 |
Pathways for energy production and sugar metabolism | ||
Central carbon metabolism | 0.00435 | 5 |
2-Oxocarboxylic acid metabolism | 0.0165 | 3 |
Glycosaminoglycan biosynthesis—heparan sulfate/heparin | 0.0113 | 3 |
Proteoglycans | 0.0337 | 8 |
Cell signaling pathways | ||
Phosphatidylinositol signaling system | 0.0489 | 5 |
TGF-beta signaling pathway | 0.0489 | 4 |