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Table 3 Stratified Cox regression analysis for risk subgroup factors of nasopharyngeal carcinoma-specific death related to surgery treatment

From: Benefits of local tumor excision and pharyngectomy on the survival of nasopharyngeal carcinoma patients: a retrospective observational study based on SEER database

Variable

Levels

Local tumor excision vs non-surgery

Pharyngectomy vs non-surgery

Surgery vs nonsurgery

p*

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

Age (year)

≥60

0.71 [0.48, 1.05]

0.09

0.72 [0.36, 1.45]

0.36

0.79 [0.58, 1.09]

0.15

0.25

<60

0.44 [0.27, 0.73]

0.002

0.20 [0.05, 0.79]

0.02

0.42 [0.27, 0.65]

0.0001

 

Sex

Male

0.42 [0.23, 0.76]

0.004

0.92 [0.34, 2.46]

0.87

0.44 [0.26, 0.74]

0.002

0.25

Female

0.67 [0.47, 0.96]

0.03

0.36 [0.16, 0.79]

0.01

0.70 [0.52, 0.94]

0.02

 

Race

White (n = 91)

0.46 [0.29, 0.71]

0.0002

0.40 [0.18, 0.89]

0.03

0.51 [0.36, 0.72]

0.0002

<0.01

Black (n = 656)

0.35 [0.11, 1.09]

0.07

0.92 [0.23, 3.73]

0.90

0.54 [0.25, 1.18]

0.12

 

Asian (n = 1806)

0.97 [0.58, 1.63]

0.91

0.24 [0.03, 2.02]

0.16

0.77 [0.47, 1.29]

0.32

 

AJCC stage

I

1.14 [0.41,3.14]

0.80

1.14 [0.15, 8.62]

0.90

1.14 [0.44, 2.93]

0.79

0.42

II

0.89 [0.43, 1.85]

0.76

0.86 [0.21, 3.51]

0.84

0.86 [0.46, 1.62]

0.64

 

III

0.35 [0.13, 0.93]

0.04

0.26 [0.04, 1.82]

0.17

0.37 [0.17, 0.84]

0.02

 

IV

0.85 [0.54, 1.35]

0.49

0.57 [0.25, 1.28]

0.17

0.76 [0.52, 1.11]

0.16

 

T stage

T1

0.69 [0.38, 1.25]

0.22

0.55 [0.17, 1.72]

0.30

0.62 [0.37, 1.07]

0.08

0.06

T2

0.58 [0.27, 1.23]

0.16

0.29 [0.04, 2.10]

0.22

0.58 [0.31, 1.10]

0.10

 

T3

0.16 [0.04, 0.63]

0.009

0.68 [0.17, 2.76]

0.59

0.29 [0.12, 0.71]

0.007

 

T4

1.09 [0.64, 1.88]

0.75

0.80 [0.30, 2.16]

0.66

1.11 [0.71, 1.72]

0.65

 

N stage

N0

0.63 [0.38, 1.04]

0.07

0.59 [0.22, 1.60]

0.30

0.71 [0.46, 1.08]

0.11

0.86

N1

0.55 [0.29, 1.03]

0.06

0.57 [0.18, 1.79]

0.34

0.52 [0.30, 0.89]

0.02

 

N2

0.55 [0.24, 1.23]

0.15

0.61 [0.20, 1.91]

0.40

0.61 [0.33, 1.16]

0.13

 

N3

0.67 [0.21, 2.12]

0.50

–

–

0.42 [0.15, 1.13]

0.09

 

M stage

M0

0.71 [0.50, 1.00]

0.05

0.53 [0.26, 1.06]

0.07

0.69 [0.51, 0.93]

0.01

0.84

M1

0.24 [0.06, 0.97]

0.05

1.63 [0.40, 6.61]

0.49

0.45 [0.18, 1.09]

0.08

 

Grade

Well

0.46 [0.10, 2.02]

0.30

1.13 [0.14, 8.87]

0.91

0.57 [0.16, 1.99]

0.38

0.07

Moderately

0.60 [0.24, 1.48]

0.27

–

–

0.36 [0.16, 0.82]

0.02

 

Poorly

0.95 [0.62, 1.47]

0.82

0.46 [0.15, 1.44]

0.18

0.85 [0.57, 1.25]

0.40

 

Undifferentiated

0.40 [0.19, 0.85]

0.02

1.78 [0.79, 4.04]

0.16

0.65 [0.37, 1.12

0.12

 

Histology

keratinizing

0.74 [0.51, 1.06]

0.09

0.31 [0.13, 0.76]

0.01

0.68 [0.50, 0.93]

0.01

0.02

Nonkeratinizing

0.39 [0.18, 0.83]

0.01

0.61 [0.20, 1.92]

0.40

0.45 [0.24, 0.82]

0.01

 

Undifferentiated

0.54 [0.20, 1.48]

0.23

2.36 [0.58, 9.66]

0.23

0.81 [0.37, 1.78]

0.60

 

Radiation

No

0.34 [0.16, 0.72]

0.005

0.16 [0.02, 1.12]

0.06

0.35 [0.19, 0.64]

0.0007

0.03

Yes

0.69 [0.48, 0.98]

0.04

0.64 [0.33, 1.23]

0.18

0.71 [0.53, 0.96]

0.02

 
  1. p* indicated the comparison of surgery vs non-surgery among subgroups
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Journal of Translational Medicine

ISSN: 1479-5876

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