Fig. 5
Multiple regression model on the associations between neuroendocrine markers (upper row), immune markers (middle row) and co-expression of genes as captured in Factor 3 from a principal component analysis (lower row). LF/HF, B-Mono, B-Eos and P-Cort are all independently and significantly associated with Factor 3, explaining 67% of the total variance. For LF/HF, B-Mono and P-Cort, the association is positive; for B-Eos the association is negative. In addition, LF/HF is significantly associated with B-Mono. P plasma, U urine, B blood, LF/HF low-frequency/high-frequency power of heart rate (an index of sympathetic vs parasympathetic balance), RMSSD square root of the mean squared differences of subsequent RR-intervals (an index of parasympathetic activity), Cort cortisol, Epi epinephrine, Mono monocytes, Eos eosinophils, Neu neutrophils, PCA principal component analysis, B regression coefficient (unstandardized), R 2 explained variance of the dependent variable in the multiple regression model