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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models

Fig. 4

Administration of AAV2-LiC-ApoE-haat-cF9 to a hemophilia B dog leads to only minimal correction of coagulation. a C57BL/6 mice were intravenously injected with 2 × 1010 vg of the AAV2-(Y-F)-M3-ApoE-hAAT-cF9 vector or 1 × 1010 vg of the AAV2-LiC-ApoE-hAAT-cF9 and levels of circulating cFIX protein were measured by ELISA at 4 weeks post gene delivery. b, c A hemophilia B dog, Bruce, was peripherally injected with 6 × 1011 vg/kg of an AAV2-LiC-ApoE-hAAT-cF9 vector and followed over time for changes in b WBCT and c % cFIX activity. Fold difference between groups in a are listed above and the amount of “*” and p value is included as reported by an unpaired T test

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