Fig. 3
From: Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models
AAV2-LiC capsid selected for murine hepatocyte tropism normalizes coagulation and induces tolerance in hemophilia B mice. Hemophilia B mice (BALB/c-F9−/Y) were intravenously injected with 1 × 1011 vg of either AAV2-LiA or AAV2-LiC ApoE-hAAT-hF9 vector and followed over time for a hFIX protein levels b % FIX coagulation activity, and c anti-hFIX IgG1 antibody titers. Horizontal dotted line in a–c denotes time of adjuvant-hFIX challenge in mice