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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models

Fig. 3

AAV2-LiC capsid selected for murine hepatocyte tropism normalizes coagulation and induces tolerance in hemophilia B mice. Hemophilia B mice (BALB/c-F9−/Y) were intravenously injected with 1 × 1011 vg of either AAV2-LiA or AAV2-LiC ApoE-hAAT-hF9 vector and followed over time for a hFIX protein levels b % FIX coagulation activity, and c anti-hFIX IgG1 antibody titers. Horizontal dotted line in ac denotes time of adjuvant-hFIX challenge in mice

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