Fig. 2
From: Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models
Hemophilia B dogs injected with two different doses of AAV2-(Y-F)-M3-ApoE-hAAT-cF9 vector do not express therapeutic levels of cFIX protein. a Whole blood clotting times (WBTC) and b cFIX activity of dogs O19 (blue 2 × 1011 vg/kg) and O58 (red 6 × 1011 vg/kg) over time. Colored arrows indicate infusion of wild-type dog plasma. Normal WBCT is indicated by shaded gray area on graph