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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Up-regulated expression of substance P in CD8+ T cells and NK1R on monocytes of atopic dermatitis

Fig. 7

Induction of NK1R expression in peripheral blood leukocytes by allergens in healthy control (HC) subjects and patients with atopic dermatitis (AD). Cells were challenged by Artemisia sieversiana wild allergen extract (ASWE), house dust mite allergen extract (HDME), or Platanus pollen allergen extract (PPE) (all at concentrations of 0.1 and 1.0 μg/ml) at 37 °C for 1 h. (A), (B), (C), (D), (E) and (F) represent NK1R+ populations of CD4+ (helper T cells), CD8+ (cytotoxic T cells), CD14+ (monocytes), CD16+ (neutrophils), CD19+ (B cells), and CD123+HLA-DR cells (basophils) in HC subjects and patients with AD, respectively. The data are displayed as a boxplot for 8 HC subjects or 10 patients with AD, which indicates the median, interquartile range, and the largest and smallest values. *P < 0.05 compared with the increased response to the corresponding medium alone control. P < 0.05 compared with the decreased response to the corresponding medium alone control. P < 0.05 compared with the response to the corresponding medium alone control of HC subject groups (paired Mann–Whitney U test)

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