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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

Fig. 2

PBMCs were evaluated for the presence of monocytic MDSCs (CD11b+CD14+CD33+HLA-DR−) at different time points post treatment initiation (a, b) and correlated to overall survival (c Pre, d Post, e fold change) or Tregs (CD3+CD4+FoxP3+CD127−) (f) using Spearmans test for nonparametric samples. Open circles in a and b indicates responding patients, as determined by having decreased activity in tumor lesions as defined by PET/CT. g The ratio of Teff/mMDSC was calculated before and at 3 weeks post treatment initiation. Significant difference was calculated using Wilcoxon testing for paired samples. GraphPad Pris was used for statistical calculations

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