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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: The role of vitamin C in the treatment of pain: new insights

Fig. 1

Proposed synthesis of endomorphin-1 by the vitamin C-dependent enzyme peptidylglycine α-amidating monooxygenase (PAM). The enzyme comprises a peptidylglycine α-hydroxylating monooxygenase (PHM) domain, which converts glycine-extended peptides into a hydroxyglycine intermediate, and a peptidyl α-hydroxyglycine α-amidating lyase (PAL) domain, which converts the hydroxyglycine intermediate into an amidated product. AA ascorbic acid, DHA dehydroascorbic acid

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