Table 2 Clinical and echocardiographic characteristics of the independent cohort used in the validation study
From: Specific circulating microRNA signature of bicuspid aortic valve disease
TAV | TAVdil | BAV | BAVdil | p | |
|---|---|---|---|---|---|
Age (years) | 39 ± 3 | 65 ± 3 | 33 ± 3 | 42 ± 3 | <0.001** |
Sex (male/female) | (8/4) | (5/2) | (11/1) | (6/6) | 0.171 |
Body weight (kg) | 70.1 ± 3.7 | 76.8 ± 3.4 | 73.25 ± 4.4 | 66.6 ± 4.2 | 0.374 |
Hypertension | 0 (0%) | 5 (71.4%) | 1 (8.3%) | 3 (25%) | 0.002** |
Hypercholesterolemia | 1 (8.3%) | 1 (14.3%) | 0 (0%) | 0 (0%) | 0.391 |
Smoker | 0 (0%) | 0 (0%) | 1 (8.3%) | 3 (25%) | 0.105 |
Aortic stenosis (mean gradient ≥20 mm Hg) | 0 (0%) | 0 (0%) | 1 (8.3%) | 2 (16.7%) | 0.507 |
Aortic regurgitation (≥II) | 0 (0%) | 4 (57.1%) | 7 (46.7.3%) | 4 (33.3%) | 0.012* |
Aortic valve gradient (mean, mm Hg) | 3.4 ± 0.2 | 3.0 ± 0.1 | 6.7 ± 1.0 | 16.5 ± 5.8 | 0.117 |
Left ventricle diastolic diameter (mm) | 50.1 ± 1.2 | 53.0 ± 2.2 | 54.8 ± 2.0 | 52.3 ± 0.9 | 0.182 |
Left ventricle systolic diameter (mm) | 29.9 ± 0.7 | 35.8 ± 2.9 | 34.7 ± 0.7 | 32.2 ± 0.7 | 0.048* |
Left ventricular ejection fraction (%) | 77.3 ± 1.6 | 61.0 ± 11.7 | 69.1 ± 2.6 | 70.7 ± 1.2 | 0.063 |
Ascending aorta diameter (mm/m2) | 15.9 ± 0.6 | 23.2 ± 0.9 | 17.6 ± 0.8 | 25.1 ± 1.2 | <0.001** |