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Table 2 List of the 100 most dysregulated genes due to the 24h effect of BE

From: 24h-gene variation effect of combined bevacizumab/erlotinib in advanced non-squamous non-small cell lung cancer using exon array blood profiling

Ensembl Gene symbol Description Gene dysregulation at 24h
ENSG00000125257 ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Up-regulated
ENSG00000114770 ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Down-regulated
ENSG00000173208 ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 Up-regulated
ENSG00000151726 ACSL1 Acyl-CoA synthetase long-chain family member 1 Down-regulated
ENSG00000135074 ADAM19 ADAM metallopeptidase domain 19 (meltrin beta) Down-regulated
ENSG00000154027 AK5 Adenylate kinase 5 Up-regulated
ENSG00000151150 ANK3 Ankyrin 3, node of Ranvier (ankyrin G) Up-regulated
ENSG00000206560 ANKRD28 Ankyrin repeat domain 28 Up-regulated
ENSG00000118520 ARG1 Arginase, liver Down-regulated
ENSG00000196914 ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 Up-regulated
ENSG00000156802 ATAD2 ATPase family, AAA domain containing 2 Up-regulated
ENSG00000085224 ATRX Alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) Up-regulated
ENSG00000023445 BIRC3 baculoviral IAP repeat-containing 3 Up-regulated
ENSG00000102010 BMX BMX non-receptor tyrosine kinase Down-regulated
ENSG00000136492 BRIP1 BRCA1 interacting protein C-terminal helicase 1 Up-regulated
ENSG00000197603 C5orf42 Chromosome 5 open reading frame 42 Up-regulated
ENSG00000152495 CAMK4 Calcium/calmodulin-dependent protein kinase IV Up-regulated
ENSG00000137812 CASC5 Cancer susceptibility candidate 5 Up-regulated
ENSG00000138778 CENPE Centromere protein E, 312 kDa Up-regulated
ENSG00000198707 CEP290 Centrosomal protein 290 kDa Up-regulated
ENSG00000106034 CPED1 Cadherin-like and PC-esterase domain containing 1 Up-regulated
ENSG00000103196 CRISPLD2 Cysteine-rich secretory protein LCCL domain containing 2 Down-regulated
ENSG00000146122 DAAM2 Dishevelled associated activator of morphogenesis 2 Down-regulated
ENSG00000035664 DAPK2 Death-associated protein kinase 2 Down-regulated
ENSG00000137628 DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 Up-regulated
ENSG00000174485 DENND4A DENN/MADD domain containing 4A Up-regulated
ENSG00000135905 DOCK10 Dedicator of cytokinesis 10 Up-regulated
ENSG00000147459 DOCK5 Dedicator of cytokinesis 5 Down-regulated
ENSG00000088387 DOCK9 Dedicator of cytokinesis 9 Up-regulated
ENSG00000178904 DPY19L3 Dpy-19-like 3 (C. elegans) Down-regulated
ENSG00000134765 DSC1 Desmocollin 1 Up-regulated
ENSG00000135636 DYSF Dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) Down-regulated
ENSG00000198919 DZIP3 DAZ interacting protein 3, zinc finger Up-regulated
ENSG00000102189 EEA1 Early endosome antigen 1 Up-regulated
ENSG00000151491 EPS8 Epidermal growth factor receptor pathway substrate 8 Up-regulated
ENSG00000089048 ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) Up-regulated
ENSG00000198734 F5 Coagulation factor V (proaccelerin, labile factor) Down-regulated
ENSG00000140525 FANCI Fanconi anemia, complementation group I Up-regulated
ENSG00000138829 FBN2 Fibrillin 2 (congenital contractural arachnodactyly) Down-regulated
ENSG00000139132 FGD4 FYVE, RhoGEF and PH domain containing 4 Down-regulated
ENSG00000122025 FLT3 Fms-related tyrosine kinase 3 Down-regulated
ENSG00000161791 FMNL3 Formin-like 3 Up-regulated
ENSG00000073910 FRY Furry homolog (Drosophila) Down-regulated
ENSG00000162654 GBP4 Guanylate binding protein 4 Up-regulated
ENSG00000182885 GPR97 G protein-coupled receptor 97 Down-regulated
ENSG00000106070 GRB10 Growth factor receptor-bound protein 10 Down-regulated
ENSG00000084110 HAL Histidine ammonia-lyase Down-regulated
ENSG00000120694 HSPH1 Heat shock 105/110 kDa protein 1 Up-regulated
ENSG00000140443 IGF1R Insulin-like growth factor 1 receptor Down-regulated
ENSG00000197081 IGF2R Insulin-like growth factor 2 receptor Down-regulated
ENSG00000115604 IL18R1 Interleukin 18 receptor 1 Down-regulated
ENSG00000115594 IL1R1 Interleukin 1 receptor, type I Down-regulated
ENSG00000115590 IL1R2 Interleukin 1 receptor, type II Down-regulated
ENSG00000109452 INPP4B Inositol polyphosphate-4-phosphatase, type II, 105 kDa Up-regulated
ENSG00000102445 KIAA0226L KIAA0226-like Down-regulated
ENSG00000137261 KIAA0319 KIAA0319 Down-regulated
ENSG00000110318 KIAA1377 KIAA1377 Up-regulated
ENSG00000054523 KIF1B Kinesin family member 1B Down-regulated
ENSG00000138182 KIF20B Kinesin family member 20B Up-regulated
ENSG00000139116 KIF21A Kinesin family member 21A Up-regulated
ENSG00000068796 KIF2A Kinesin heavy chain member 2A Up-regulated
ENSG00000184445 KNTC1 Kinetochore associated 1 Up-regulated
ENSG00000126777 KTN1 Kinectin 1 (kinesin receptor) Up-regulated
ENSG00000123384 LRP1 Low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) Down-regulated
ENSG00000186205 MARC1 Mitochondrial amidoxime reducing component 1 Down-regulated
ENSG00000257335 MGAM Maltase-glucoamylase (alpha-glucosidase) Down-regulated
ENSG00000171843 MLLT3 Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 Up-regulated
ENSG00000196549 MME Membrane metallo-endopeptidase Down-regulated
ENSG00000100985 MMP9 Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase) Down-regulated
ENSG00000051825 MPHOSPH9 M-phase phosphoprotein 9 Up-regulated
ENSG00000138119 MYOF Myoferlin Up-regulated
ENSG00000049759 NEDD4L Neural precursor cell expressed, developmentally down-regulated 4-like Up-regulated
ENSG00000184613 NELL2 NEL-like 2 (chicken) Up-regulated
ENSG00000173145 NOC3L Nucleolar complex associated 3 homolog (S. cerevisiae) Up-regulated
ENSG00000179299 NSUN7 NOL1/NOP2/Sun domain family, member 7 Down-regulated
ENSG00000111581 NUP107 Nucleoporin 107 kDa Up-regulated
ENSG00000159339 PADI4 Peptidyl arginine deiminase, type IV Down-regulated
ENSG00000123836 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Down-regulated
ENSG00000075651 PLD1 Phospholipase D1, phosphatidylcholine-specific Down-regulated
ENSG00000101868 POLA1 Polymerase (DNA directed), alpha 1 Up-regulated
ENSG00000080839 RBL1 Retinoblastoma-like 1 (p107) Up-regulated
ENSG00000257743 RP11-1220K2.2 Putative inactive maltase-glucoamylase-like protein LOC93432 Down-regulated
ENSG00000226891 RP11-182I10.3 Uncharacterized LOC101927084 Down-regulated
ENSG00000258476 RP11-76E17.3 NA Down-regulated
ENSG00000140386 SCAPER S phase cyclin A-associated protein in the ER Up-regulated
ENSG00000018280 SLC11A1 Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 Down-regulated
ENSG00000140090 SLC24A4 Solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 Down-regulated
ENSG00000112053 SLC26A8 Solute carrier family 26, member 8 Down-regulated
ENSG00000157800 SLC37A3 Solute carrier family 37 (glycerol-3-phosphate transporter), member 3 Down-regulated
ENSG00000136824 SMC2 Structural maintenance of chromosomes 2 Up-regulated
ENSG00000163029 SMC6 Structural maintenance of chromosomes 6 Up-regulated
ENSG00000009694 TENM1 Teneurin transmembrane protein 1 Down-regulated
ENSG00000169902 TPST1 Tyrosylprotein sulfotransferase 1 Down-regulated
ENSG00000198677 TTC37 Tetratricopeptide repeat domain 37 Up-regulated
ENSG00000155657 TTN Titin Up-regulated
ENSG00000120800 UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) Up-regulated
ENSG00000197969 VPS13A Vacuolar protein sorting 13 homolog A (S. cerevisiae) Up-regulated
ENSG00000163625 WDFY3 WD repeat and FYVE domain containing 3 Down-regulated
ENSG00000213799 ZNF845 Zinc finger protein 845 Up-regulated
ENSG00000167232 ZNF91 Zinc finger protein 91 Up-regulated
  1. Information includes the Ensembl code, the gene symbol, description and sign of dysregulation. For convenience, the genes are ordered alphabetically