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Table 3 Changes in the concentrations of specific oxylipins, CRP and WCC between time-points

From: Longitudinal analysis of serum oxylipin profile as a novel descriptor of the inflammatory response to surgery

Analyte Pre- vs. early Early vs. late Pre- vs. late
Fold change p value Fold change p value Fold change p value
CRP 30.00 (3.26–36.47) 0.007 1.07 (0.74–2.42) 0.213 13.25 (4.95–34.89) 0.0002
WCC 1.44 (1.25–1.64) <0.0001 0.78 (0.68–0.86) 0.045 1.15 (0.85–1.47) 0.13
9-HODE 0.71 (0.55–0.90) 0.028 1.01 (0.71–1.46) 0.295 0.71 (0.42–1.48) 0.891
13-HODE 0.72 (0.61–1.10) 0.039 1.06 (0.70–1.60) 0.117 0.73 (0.52–1.47) 0.955
5-HETE 0.89 (0.70–1.22) 0.138 1.13 (0.80–1.62) 0.18 1.04 (0.72–1.71) 0.445
8-HETE 0.74 (0.25–1.18) 0.052 1.54 (1.01–2.54) 0.011 1.28 (0.96–1.72) 0.426
12-HETE 0.86 (0.41–1.74) 0.214 1.62 (0.64–4.46) 0.065 2.57 (0.66–5.95) 0.467
12-Oxo-LTB4 0.53 (0.28–1.05) 0.147 1.00 (0.49–3.16) 0.118 0.51 (0.31–1.00) 0.039
8,9-DHET 0.62 (0.34–0.88) 0.024 1.35 (0.94–3.57) 0.014 0.93 (0.67–1.79) 0.799
5,6-DHET 0.94 (0.08–1.00) 0.035 1.00 (1.00–14.03) 0.151 1.00 (1.00–1.39) 0.226
11,12-DHET 0.70 (0.37–0.93) 0.016 1.23 (0.88–2.06) 0.038 0.87 (0.63–1.28) 0.474
14,15-DHET 0.66 (0.42–0.98) 0.043 1.19 (1.08–1.93) 0.03 1.03 (0.62–1.72) 0.665
PGF2α 0.99 (0.29–1.03) 0.311 1.00 (0.19–6.44) 0.377 1.50 (0.41–7.72) 0.46
6-Keto-PGF1α 1.00 (0.64–1.61) 0.914 1.00 (0.41–1.43) 0.127 1.00 (0.44–1.14) 0.468
TXB2 0.51 (0.05–3.67) 0.227 1.21 (0.25–7.56) 0.365 1.70 (0.23–13.32) 0.769
11-HETE 1.47 (1.18–1.65) 0.005 1.20 (0.89–2.10) 0.068 1.17 (0.60–1.86) 0.756
14-HDoHE 0.96 (0.41–1.76) 0.275 1.26 (0.75–2.56) 0.057 1.51 (0.54–3.01) 0.415
C20:5 (EPA) 0.77 (0.51–1.21) 0.18 1.09 (0.66–1.61) 0.976 0.90 (0.56–1.45) 0.374
C20:4 (AA) 0.92 (0.79–1.29) 0.749 1.14 (0.85–1.50) 0.083 1.19 (0.90–1.62) 0.028
15(S)-HETE 0.63 (0.52–0.94) 0.005 1.22 (0.78–1.46) 0.238 0.81 (0.74–1.31) 0.692
C22:6 (DHA) 0.80 (0.58–1.20) 0.352 1.02 (0.78–1.32) 0.948 0.81 (0.66–1.41) 0.675
17-HDoHE 0.82 (0.63–1.26) 0.122 1.19 (0.75–1.75) 0.098 1.16 (0.73–1.27) 0.778
C20:3 (DGLA) 0.96 (0.66–1.27) 0.51 1.00 (0.79–1.50) 0.584 0.98 (0.76–1.34) 0.879
  1. Values are reported as median fold change (interquartile range). Italics indicate statistically significant comparisons