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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Dynamic and specific immune responses against multiple tumor antigens were elicited in patients with hepatocellular carcinoma after cell-based immunotherapy

Fig. 4

The dynamic immune responses against each kind of antigen were induced by MASCT. The specific immune responses of HCC patients’ PBMCs against each kind of antigens were detected by IFNγ ELISPOT assay. a The spots of IFNγ secreting T cells on the time point of week 1 (baseline) and week 16 (after the first course of MASCT treatment) were counted and compared. b The spots of IFNγ secreting T cells on the time point of week 1 (baseline) and week 31 (after the second course of MASCT treatment) were counted and compared. The shown numbers indicated the IFNγ+ spots numbers in 200,000 cells, and were normalized by minus the IFNγ+ spots numbers of the PBMCs stimulated with irrelevant peptide. The clear MASCT-induced antigen-specific immune responses were marked in grey as defined by at least ten more spots than baseline

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