Skip to main content

Advertisement

Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Veliparib in combination with radiotherapy for the treatment of MGMT unmethylated glioblastoma

Fig. 2

Combination of veliparib and radiotherapy. Patient derived cell lines were treated with veliparib (10 μM) for 2 h before irradiation with 0, 1, 2 and 4 GY. Cells were seeded in wells and the ability to form clones was monitored over a 10-day period. a G18; b WK1; c G53; d RN1; e G54 and f G57. Bar graphs represent the percentage of clones counted with respect to the control. g Veliparib and radiotherapy induce apoptotic cell death in patient derived cell lines. RN1, G54, G57 and G89 cells were treated with veliparib (10 μM) for 2 h before irradiation with 2 GY. h Protein expression of Rad50 and Mre11 were assessed in untreated PDCLs, RN1, G54, G57 and G89. i Quantification of Rad50 and Mre11 protein expression for each PDCL. Error bars represent the standard deviation of three individual experiments. Significance determined by student t-test where ***(p < 0.001); **(p < 0.01); *(p < 0.05)

Back to article page