Skip to main content

Table 1 Predictive value of uC3M and uC1M at 6 (A) weeks and correlation at 12 weeks (B) with histological fibrotic markers at week 12 in untreated ADR-rats and FTY720-treated ADR-rats

From: Urinary collagen degradation products as early markers of progressive renal fibrosis

 

uC3M/Cr 6 weeks

uC1M/Cr 6 weeks

Rs

P value

Rs

P value

A.

 ADR untreated rats

  Histological markers—12 weeks

   Collagen type III

0.381

0.352

0.262

0.531

   Fibronectin

0.238

0.570

0.190

0.651

   Myofibroblasts(α-SMA)

0.333

0.420

0.310

0.456

   PDGF-β receptor

0.524

0.183

0.405

0.320

   Tubulointerstitial fibrosis (PAS)

0.687

0.060

0.674

0.067

   Hyaluronan

0.810

0.015

0.571

0.139

 

uC3M/Cr 12 weeks

uC1M/Cr 12 weeks

Rs

P value

Rs

P value

B.

 ADR-rats (pooled)

  Histological markers—12 weeks

   Collagen type III

0.529

0.035

0.403

0.122

   Fibronectin

0.074

0.787

0.194

0.471

   Myofibroblasts(α-SMA)

0.600

0.014

0.497

0.050

   PDGF-β receptor

0.841

<0.0001

0.656

0.006

   Tubulointerstitial fibrosis (PAS)

0.831

0.000

0.694

0.003

   Hyaluronan

0.807

0.000

0.654

0.006

  1. Significant differences are highlighted in italics. Spearmann rank correlation was done on Z-values of all variables