Fig. 1

Effects of Adriamycin with or without FTY720 treatment on collagen degradation markers. Effects of Adriamycin are shown without (left panels) and with FTY720 treatment (right panels) on pC3M (a, b), uC3M (c, d), and uC1M (e, f). uC3M and uC1M concentrations were expressed per mg urinary creatinine. Open boxes represent controls, dark grey boxes ADR-rats. *P < 0.05, **P < 0.01, ***P < 0.001. Statistical differences between all groups at the same time-point were tested using the Kruskall-Wallis test (Dwass-Steel-Critchlow-Fligner post-test) and differences over time by using the Friedmann test (Iman and Davenport post-test)