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Table 3 Survival analysis

From: Epidermal growth factor receptor and epididymis invasion as prognostic biomarkers in clinical stage I testicular germ cell tumours

Variable Relapse-free survival
5 years-RFS (%) HR (95% CI) p value
A. Univariate analysis
Histology
 NS 59.1 4.8 (1.4–16.3) 0.012
 Seminoma 90.3 1  
Age
 ≤30 61.5 2.5 (1–6.5) 0.056
 >30 83.3 1  
LVI
 Yes 54.5 3.2 (1.3–8.2) 0.014
 No 83.0 1  
Tumor size (cm)
 ≥4 57.1 4.5 (1.5–13.5) 0.008
 <4 87.9 1  
Rete testis invasion
 Yes 54.5 4.5 (1.5–13.3) 0.006
 No 88.4 1  
Epididymis invasion
 Yes 25.0 3.6 (1.4–9.3) 0.008
 No 81.3 1  
hMLH1 expression
 Null/low 66.7 2 (0.7–5.7) 0.178
 Normal 79.3 1  
hMSH2 expression
 Null/low 81.3 0.66 (0.2–2.3) 0.524
 Normal 70.0 1  
EGFR expression
 Positive 52.9 3.5 (1.3–9.8) 0.016
 Negative 82.1 1  
Variable Relapse-free survival
  HR (95% CI) p value
B. Multivariate analysis
Histology
 NS   ns
 Seminoma   
Age
 ≤30   ns
 >30   
LVI
 Yes   ns
 No   
Tumor size (cm)
 ≥4    ns
 <4    
Rete testis invasion
 Yes   ns
 No   
Epididymis invasion
 Yes 7.6 (2.4–23.7) 0.001
 No 1  
EGFR expression
 Positive   ns
 Negative