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Table 4 Comparison of the portion of CD4+ and CD8+ cells in CAR T cells manufactured from PBMC concentrates enriched for lymphocytes using 3 different methods

From: Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells

Lymphocyte enrichment method CAR T cell type
CD19 GD2
n CD4 CD8 n CD4 CD8
Anti-CD3/CD28 beads 6 54.5 ± 26.1 35.0 ± 25.1 6 45.8 ± 12.3 48.4 ± 14.7
Anti-CD3/CD28 beads + plastic adherence 16 57.3 ± 15.7 38.4 ± 14.8 5 48.0 ± 48.7 40.0 ± 10.1
Elutriation 8 50.6 ± 14.8 42.4 ± 16.5 5 38.1 ± 17.1 53.2 ± 15.1