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Table 2 Comparison of the composition of PBMC concentrates and the elutriated lymphocyte fraction used to manufacture CD19- and GD2-CAR T cells

From: Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells

Cell type CAR T cell type
CD19 GD2 All
n PBMC Elutriated lymphs n PBMC Elutriated Lymphs n PBMC Elutriated lymphs
CD3+ 8 49.0 ± 23.1 62.1 ± 24.4a 5 42.2 ± 17.0 58.0 ± 23.0a 13 49.3 ± 22.5 64.6 ± 25.5a
CD14+ 8 17.2 ± 11.4 3.5 ± 1.7a 4 20.9 ± 9.7 3.9 ± 3.2a 12 19.9 ± 13.7 3.6 ± 4.8a
CD15+ 8 8.2 ± 15.2 4.1 ± 10.6 4 3.9 ± 2.8 0.8 ± 1.4 12 6.9 ± 12.0 2.9 ± 8.2a
CD19+ 8 13.8 ± 16.9 13.4 ± 16.4 2 10.4 ± 6.7 14.5 ± 9.2 10 14.0 ± 14.7 11.9 ± 8.6
CD56+ 8 7.4 ± 4.9 12.6 ± 8.5a 2 4.8 ± 2.8 6.8 ± 3.8 10 7.2 ± 5.0 11.9 ± 8.6a
  1. ap < 0.05 Paired T-tests of pre- and post-elutriation samples
  2. Values represent the mean ± SD