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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Bone Morphogenetic Proteins and myostatin pathways: key mediator of human sarcopenia

Fig. 5

Analysis of the expression of myostatin and phosphorylated Smad1-5-8. a Graph display the expression of myostatin and phosphorylated Smad1-5-8 in muscle biopsies of OA, OP and CTRL patients. b Rare myostatin positive fibers in a muscle tissue of OA patient (4×). c Muscle tissue of OP patient characterizes by numerous myostatin positive fibers (4×). d Muscle of a CTRL patient characterize by no expression of myostatin (4×). e Image shows muscle tissue of OA patient with numerous phosphorylated Smad1-5-8 positive nuclei (arrows) (40×). f Muscle of OP patient with phosphorylated Smad1-5-8 negative nuclei (arrows) (40×). g Image displays muscle biopsy of CTRL patient with numerous phosphorylated Smad1-5-8 positive nuclei (arrows)

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