Fig. 4

Analyses of vascular characteristics. Vascular characteristics were investigated in tumor sections prepared from mice treated for 4 days with vehicle (white bars) or 100 mg/kg imatinib (grey bars). For quantification we used at least 10 random fields of sections per tumor. a The number of CD31 positive blood vessels, b perimeter of CD31-positive blood vessels, c mean area of CD31-positive blood vessels area per vessels, d desmin-positive cells (number per CD31-positive vessel), e ASMA positive cells (number per CD31-positive vessel) and f NG2 positive cells (number per CD31-positive vessel). Data are presented as mean ± SEM and statistically significant differences (Student’s t-test; p < 0.05) compared to vehicle treatment are indicated by asterisk. The numbers of tumors in vehicle and imatinib treatment groups, respectively, were: KAT-4 (12 and 13), CT-26 (7 and 6) and B16/BB (7 and 7)