Fig. 2
Imatinib reduces IFP in KAT-4 and CT-26 carcinomas. Mice bearing subcutaneous tumors were treated for 4 days with vehicle (n = 11; white bars) or 100 mg/kg imatinib (n = 8; grey bars). All measurements were made 4 h after the last administration. a Tumor IFP was measured using the wick-in-needle technique. Data are averages from at least 7 different tumors in each group. b Oxygen pressure was averaged for the individual tumor (at least three measurements) and the data shown is the average of these averages. KAT-4, n = 5 treated and 5 untreated, CT-26, n = 9 treated and 8 untreated, B16BB n = 5 treated and 5 untreated. c. The fraction of oxygen pressure with pO2 ≤ 25 mmHg measured in the same tumors as in B. d Blood flow was averaged for each tumor and the data presented is the average of the averages calculated for each tumor (in turn being the average of at least three successful measurements). KAT-4, n = 5 treated and 5 untreated, CT-26, n = 9 treated and 8 untreated, B16BB n = 5 treated and 5 untreated. Statistical analysis: a, b one-way ANOVA with Duncan adjustment; c Mann–Whitney U Rank; d Chi Square with Yates correction for continuity. Statistically significant differences (p < 0.05) compared to vehicle treatment are indicated asterisk