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Table 3 Association of Mφ with patients’ clinical characteristics

From: Distinct patterns and prognostic values of tumor-infiltrating macrophages in hepatocellular carcinoma and gastric cancer

Characteristics CD204+ Mφsa P b CD169+ Mφsa P b
Low High Low High
HCC patients
 Gender (male/female) 73/19 81/10 0.104 75/19 81/10 0.105
 HBV infection (no/yes) 7/85 11/80 0.333 8/86 11/83 0.629
 Alpha-fetoprotein, ng/mL (≤25/>25) 42/50 30/61 0.096 36/58 38/56 0.881
 Child–Pugh class (A/B) 85/7 85/6 1.000 89/5 86/8 0.567
 Tumor number (single/multiple) 78/14 61/30 0.006 69/25 75/19 0.389
 Tumor size, cm (≤5/>5) 48/44 28/63 0.004 38/56 42/52 0.658
 Vascular invasion (absent/present) 87/5 85/6 0.767 88/6 89/5 1.000
 TNM stage (I/II + III) 72/20 53/38 0.004 63/31 67/27 0.636
 Histological grade (I/II/III/other) 71/21 50/41 0.002 68/26 57/37 0.122
GC patients
 Gender (male/female) 45/21 51/14 0.237 45/21 50/16 0.439
 Tumor size, cm (≤4/>4) 23/43 20/45 0.711 22/44 23/43 1.000
 Tumor depth (pT1 + pT2 pT3/pT4) 20/46 21/44 0.852 22/44 24/42 0.855
 Lymph node metastasis (pN0 + pN1/pN2 + pN3) 32/34 23/42 0.158 28/38 29/37 1.000
 TNM stage (I + II vs. III + IV) 19/47 15/50 0.551 16/50 21/45 0.439
 Histological grade (I + II/III/other) 19/42/5 14/45/4 0.637 22/37/6 13/49/4 0.112
  1. HCC hepatocellular carcinoma, GC gastric cancer, HBV hepatitis B virus, TNM tumor-lymph node-metastasis
  2. aData were missing for these variables in some patients: CD204+ Mφs, n = 183 and CD169+ Mφs, n = 188 in HCC; CD204+ Mφs, n = 131 and CD169+ Mφs, n = 132 in HCC
  3. bItalic values indicate significance of p value (p < 0.05)