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Table 2 Univariate and multivariate analyses of variables associated with overall survival

From: Distinct patterns and prognostic values of tumor-infiltrating macrophages in hepatocellular carcinoma and gastric cancer

Variables Univariate Multivariate
HR 95% CI P a HR 95% CI P a
HCC patients
 Gender (male/female) 1.333 0.747–2.377 0.331    
 HBV infection (no/yes) 0.863 0.431–1.729 0.678    
 Alpha-fetoprotein, ng/mL (≤25/>25) 1.023 1.003–1.043 0.027    NA
 Child–Pugh class (A/B) 1.626 0.782–3.378 0.193    
 Histological grage (I/II/III/other) 1.42 0.901–2.237 0.131    
 Tumor number (single/multiple) 3.178 2.008–5.031 < 0.0001    NA
 Tumor size, cm (≤5/>5) 1.838 1.154–2.927 0.01 1.614 0.997–2.613 0.051
 Vascular invasion (absent/present) 3.832 1.825–8.046 < 0.0001 2.667 1.208–5.888 0.015
 TNM stage (I vs. II + III) 3.383 2.164–5.289 < 0.0001 2.838 1.765–4.564 0.0002
 \( {\text{CD2}}0 4_{IT}^{ + } \) cells (low/high) 1.922 1.217–3.034 0.005 2.125 1.298–3.478 0.003
 \( {\text{CD169}}_{IT}^{ + } \) cells (low/high) 0.561 0.358–0.878 0.011 0.436 0.270–0.703 0.001
GC patients
 Gender (male/female) 1.189 0.702–2.013 0.52    
 Tumor size, cm (≤4/>4) 1.655 0.951–2.881 0.075    
 Tumor depth (pT1 + pT2 + pT3/pT4) 1.251 0.744–2.105 0.398    
 Lymph node metastasis (pN0 + pN1/pN2 + pN3) 1.999 1.192–3.353 0.009 2.012 1.178–3.437 0.011
 TNM stage (I + II vs. III + IV) 2.031 1.103–3.738 0.023    NA
 Histological grage (I/II/III/other) 1.18 0.772–1.804 0.445    
 \( {\text{CD2}}0 4_{IT}^{ + } \) cells (low/high) 1.033 0.625–1.709 0.899    
 \( {\text{CD169}}_{IT}^{ + } \) cells (low/high) 0.569 0.343–0.943 0.029 0.587 0.354–0.974 0.039
  1. Cox proportional hazards regression model; variables that were associated with overall survival in the univariate analysis were adopted as covariates in the multivariate analysis and were entered into the equation using the forward likelihood ratio method
  2. HCC hepatocellular carcinoma, GC gastric cancer, HBV hepatitis B virus, TNM tumor-lymph node-metastasis, CI confidence interval, NA not applicable, IT intra-tumor
  3. aItalic values indicate significance of p value (p < 0.05)