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Table 2 Univariate and multivariate analyses of variables associated with overall survival

From: Distinct patterns and prognostic values of tumor-infiltrating macrophages in hepatocellular carcinoma and gastric cancer

Variables

Univariate

Multivariate

HR

95% CI

P a

HR

95% CI

P a

HCC patients

 Gender (male/female)

1.333

0.747–2.377

0.331

   

 HBV infection (no/yes)

0.863

0.431–1.729

0.678

   

 Alpha-fetoprotein, ng/mL (≤25/>25)

1.023

1.003–1.043

0.027

  

NA

 Child–Pugh class (A/B)

1.626

0.782–3.378

0.193

   

 Histological grage (I/II/III/other)

1.42

0.901–2.237

0.131

   

 Tumor number (single/multiple)

3.178

2.008–5.031

< 0.0001

  

NA

 Tumor size, cm (≤5/>5)

1.838

1.154–2.927

0.01

1.614

0.997–2.613

0.051

 Vascular invasion (absent/present)

3.832

1.825–8.046

< 0.0001

2.667

1.208–5.888

0.015

 TNM stage (I vs. II + III)

3.383

2.164–5.289

< 0.0001

2.838

1.765–4.564

0.0002

 \( {\text{CD2}}0 4_{IT}^{ + } \) cells (low/high)

1.922

1.217–3.034

0.005

2.125

1.298–3.478

0.003

 \( {\text{CD169}}_{IT}^{ + } \) cells (low/high)

0.561

0.358–0.878

0.011

0.436

0.270–0.703

0.001

GC patients

 Gender (male/female)

1.189

0.702–2.013

0.52

   

 Tumor size, cm (≤4/>4)

1.655

0.951–2.881

0.075

   

 Tumor depth (pT1 + pT2 + pT3/pT4)

1.251

0.744–2.105

0.398

   

 Lymph node metastasis (pN0 + pN1/pN2 + pN3)

1.999

1.192–3.353

0.009

2.012

1.178–3.437

0.011

 TNM stage (I + II vs. III + IV)

2.031

1.103–3.738

0.023

  

NA

 Histological grage (I/II/III/other)

1.18

0.772–1.804

0.445

   

 \( {\text{CD2}}0 4_{IT}^{ + } \) cells (low/high)

1.033

0.625–1.709

0.899

   

 \( {\text{CD169}}_{IT}^{ + } \) cells (low/high)

0.569

0.343–0.943

0.029

0.587

0.354–0.974

0.039

  1. Cox proportional hazards regression model; variables that were associated with overall survival in the univariate analysis were adopted as covariates in the multivariate analysis and were entered into the equation using the forward likelihood ratio method
  2. HCC hepatocellular carcinoma, GC gastric cancer, HBV hepatitis B virus, TNM tumor-lymph node-metastasis, CI confidence interval, NA not applicable, IT intra-tumor
  3. aItalic values indicate significance of p value (p < 0.05)