Fig. 4
From: Circulating tumor cells capture disease evolution in advanced prostate cancer
Identification of RB1 nonsense mutation in CRPC tissue and CTC samples. a Integrative Genomics Viewer [28] images of the S816X mutation identified in CRPC and CTC1, but not treatment-naïve sample. The brown bars in the middle panels represent the mutated nucleotide and its position within the sequencing reads. The histograms in the upper panels summarize the fraction of reference (gray or blue) or mutated (brown) reads. b Hematoxylin-Eosin stain (top) and immunohistochemical analysis of PSA (middle) or synaptophysin protein (bottom) of the CRPC liver biopsy