Fig. 4

Low percentage of fetal demise in the tacrolimus-treated HFD-dNONcNZO dams is linked in part to restored spiral artery (SA) remodeling during gestation. a Representative spiral artery histopathological analysis at gd10.5 revealing restricted remodeling of these structures in the HFD-dNONcNZO dams as measured in their significantly higher wall:lumen ratio (b), narrower lumen (c) and thicker SA walls (d). Direct causal relationship existed between  % FGR and restricted SA W:L ratio at gd10.5 in the HFD-dNONcNZO dams (e). N = a minimum of 7 dams/group and two experimental repeats, *p < 0.01 at 95% confidence