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Table 3 Multivariate Cox regression analysis

From: Association of osteopontin with specific prognostic factors and survival in adjuvant breast cancer trials of the Hellenic Cooperative Oncology Group

Disease-free survival HR 95% CI p value
Number of positive nodes
 ≥4 versus 1–3 2.51 1.88–3.63 <0.001
Tumor size
 2–5 cm versus ≤2 cm 1.45 1.08–1.95 0.013
 >5 cm versus ≤2 cm 1.65 1.10–2.48 0.015
Adjuvant HT
 Yes versus no 0.69 0.51–0.93 0.016
OPN mRNA expression
 High versus low 1.34 1.04–1.71 0.022
Overall survival
Number of positive nodes
 ≥4 versus 1–3 3.59 2.48–5.19 <0.001
Tumor size
 2–5 cm versus ≤2 cm 1.59 1.13–2.34 0.009
 >5 cm versus ≤2 cm 1.87 1.18–2.97 0.008
Adjuvant HT
 Yes versus no 0.55 0.39–0.76 <0.001
OPN mRNA expression
 High versus low 1.54 1.16–2.05 0.003
  1. HR hazard ratio, CI confidence interval