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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression

Fig. 7

T10 cells produce more IL-10 and less IFNγ than control Tm cells in response to donor- but not third party-mDC stimulation. T10 or control Tm cells were stimulated with donor-mDC or third party-mDC. Cytokine-forming units (CFU) were detected by dual ELISPOT for IFNγ and/or IL-10. Number of CFU/100,000 cells is shown. Bars represent mean value of each dataset ±SD (n = 3 experiments) (a). T10 or control Tm cells were stimulated with donor-mDC. IL-10 and IFNγ measured in the supernatant 48 h after culture by ELISA is shown. One dot represents one experiment with buffy coats from healthy donors (each symbol depicts one donor and different shapes represent different donor pairs). Lines represent mean value of each data set ± SD (ns, **p < 0.005 Mann–Whitney test) (b)

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