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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression

Fig. 6

Donor-specific suppression of CD4+ T cell proliferation by T10 cells correlates with Tr1-cell content. CD4+ T cells were stimulated with donor mDC (or third party mDC—when numbers of T10 cells permitted) in the presence or absence of autologous T10 cells. Percentages of suppression by T10 cells are shown. One dot represents one experiment with buffy coats from healthy donors (each symbol depicts one donor and different shapes represent different donor pairs). Lines represent mean value of each data set ±SD (*p ≤ 0.05 Wilcoxon matched pairs test) (a). Percentages of Tr1-cell content within T10 cells is plotted against percentage of suppression by T10 cells. One dot represents one experiment. Numbers represent anergy levels measured on each T10-cell preparation. Line represents linear regression (b)

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