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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: HIF-1α inhibitor echinomycin reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect

Fig. 3

HIF-1α inhibitor echinomycin increases number of Tregs in lymphoid organs in aGVHD mice. Lethally irradiated Balb/c mice were infused with allogeneic bone marrow cells and splenic T cells from C57BL/6 mice to generate aGVHD. Mice were treated with vehicle or echinomycin, and sacrificed on days 14 or 21. Intracellular expression of Foxp3, IL-17, or IFN-γ in donor-derived CD4 T cells in the spleen and MLN were determined. Number of CD25+Foxp3+, IL-17+, or IFN-γ+ CD4 T cells on day 14 in the spleen (a) and MLN (b), as well as on day 21 in the spleen (c) and MLN (d) are shown. Bar graphs are shown as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Data are representatives of three independent experiments with n = 5 per group

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