Identification of miRNA-mRNA crosstalk in CD4+ T cells during HIV-1 infection by integrating transcriptome analyses

Table 3 Functional annotation of putative target genes with p < 0.05

Comparison groups		GO ID	Function	P value	KEGG ID	Function	P value
LTNPs versus UCs miR-212-3p, miR-494-3p, miR-939-5p, miR-1225-5p, miR-513a-5p	Biological process	0010646	Regulation of cell communication	0.0042	NR	NR	NR
		0009966	Regulation of signal transduction	0.0079
		0009968	Negative regulation of signal transduction	0.010
		0050793	Regulation of developmental process	0.011
		0045579	Positive regulation of cell differentiation	0.011
	Cellular component	0044424	Intracellular part	0.046
	Molecular function	NR	NR	NR
CPs versus UCs miR-212-3p, miR-575, miR-574-5p, miR-513b-5p, miR-940, miR-939-5p, miR-494-3p, miR-630, miR-513a-5p, miR-1225-5p	Biological process	0007167	Enzyme linked receptor protein signaling pathway	0.024	Hsa04144	Endocytosis	0.025
		0007168	Receptor quanylyl cyclase signaling pathway	0.029	Hsa00230	Purine metabolism	0.046
		0050878	Regulation of body fluid level	0.031
		0006575	Cellular amino acid derivative metabolic process	0.046
	Cellular component	0044464	Cell part	0.0058
		0005623	Cell	0.0058
		0009898	Internal side of plasma membrane	0.015
		0044459	Plasma membrane part	0.039
		0044424	Intracellular part	0.043
	Molecular function	0043167	Ion binding	0.030
		0004383	Quanylate cyclase activity	0.034
		0046872	Metal ion binding	0.040
		0043169	Cation binding	0.044
		0046914	Transition metal ion binding	0.049

ISSN: 1479-5876