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Table 5 Changes in neurodevelopment test scores according to randomization

From: Neuroregenerative potential of intravenous G-CSF and autologous peripheral blood stem cells in children with cerebral palsy: a randomized, double-blind, cross-over study

 

Before randomization (M0–M1)

After randomization (M1–M7 or M7–M13)

p*

Placebo

mPBMC

p +

GMFM

1.6738

0.4000

0.3725

0.479

0.001

PEDI_C

2.2787

0.5180

0.4928

0.764

0.006

PEDI_M

3.0212

0.6187

0.5419

0.998

0.005

PEDI_F

3.6106

0.6665

0.6536

0.930

0.042

PEDI_CC

2.4127

0.6115

0.5549

0.736

0.057

PEDI_MC

1.3191

0.5366

0.2558

0.092

0.030

PEDI_FC

2.5148

1.1481

0.6079

0.040

0.022

QUEST

9.0497

1.0815

1.3392

0.949

0.047

  1. mPBMC mobilized peripheral blood marrow cell; GMFM gross motor function measure; PEDI_C pediatric evaluation of disability inventory self-care; PEDI_M pediatric evaluation of disability inventory mobility; PEDI_F pediatric evaluation of disability inventory social function; PEDI_CC pediatric evaluation of disability inventory mobility self-care with caregiver assistance; PEDI_MC pediatric evaluation of disability inventory mobility with caregiver assistance; PEDI_FC pediatric evaluation of disability inventory mobility social function with caregiver assistance; QUEST quality of upper extremity skills test
  2. M0, M1, M7 and M13 refer to months after enrollment
  3. + p indicates statistical significances of items between placebo and mPBMC groups
  4. * p indicates statistical significances of items between before randomization and after randomization