Fig. 2

Baseline B cell repertoires. Baseline B cell repertoires in six control, seven non-responding and eight responding candidates prior to receiving desensitization therapy. a The fraction of molecules corresponding to the most abundant sequence. b The fraction of unique sequences detected after subsampling to 1000 molecules in each sample. c Histogram of in-frame CDR3 lengths averaged over the samples in each group. d V-gene usage averaged across samples in each group. e Cross correlation matrix of the abundances in all V-J gene combinations between all samples (individual elements above the diagonal) and averaged within each group (large regions below diagonal). f Molecule-weighted isotype abundance in each sample. g Fraction of molecules in each sample containing a switched isotype (i.e., sum of IgG and IgA from d). h Molecule-weighted mutation frequency for each isotype. i Mutation frequency averaged across isotypes for each sample (data from f)