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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Near infrared fluorescent imaging of brain tumor with IR780 dye incorporated phospholipid nanoparticles

Fig. 6

Real-time NIRF imaging of IR780-phospholipid micelles using the GBM spontaneous mouse model. a Representative GBM tumor section showing invasive tumor growth in H&E staining. b A duplicate unstained brain section showing tumor targeting of IR780-phospholipid micelles by NIRF microscopic imaging. GBM hallmarks including invasive tumor growth penetrating into normal brain (c), and anaplastic nuclear (arrowed yellow and insert) and glomeruloid body-like vascular structure (arrowed red, d). e Whole-body bioluminescent and NIRF imaging of a tumor-bearing mouse at different times post injection of IR780-phospholipid micelles. f Intratumoral accumulation of IR780-micelles at day 3 post injection as imaged in the lateral position. Note that bioluminescence and fluorescence signals come from same area

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