Fig. 5

In vivo NIRF imaging of IR780-phospholipid micelles with the U87M2/luc orthotopic model. a Nude mice bearing U87M2/luc orthotopic tumors were dosed with IR780-phospholipid micelles via tail vein injection. Post injection, sequential BLI and NIRF images were taken at each time point as indicated using the AMI1000 optical imager at Ex/Em = 745/810 nm. Note that the healthy control mouse (the 1st one on the left) did not show any signals. b NIRF image of dissected mouse brains after the last whole body imaging. c Representative NIRF image of dissected brain and other organs from a mouse bearing U87M2/luc orthotopic tumor. Upper brain, lung, heart and liver; Middle spleen, kidneys, stomach and intestines; Lower muscle, skin