Table 2 Blood and renal parameters of Göttingen minipigs
OP I | After OP I | OP II | After OP II | Termination | Norm | |
|---|---|---|---|---|---|---|
Kidney values (serum) | 0 weeks | 2 weeks | 6 weeks | 8 weeks | 18/22/32 weeks | |
Total protein (g/dl) | 6.4 ± 0.7 | 5.2 ± 0.5 | 6.7 ± 0.5 | 6.1 ± 0.3 | 6.5 ± 0.7 | 4.5–8.5 |
Urea (mmol/l) | 2.4. ± 1.1 | 1.8 ± 0.1 | 2.2 ± 0.9 | 3.7 ± 3.7 | 2.2 ± 0.9 | 3.3–8.3 |
Creatinine (µmol/l) | 107.5 ± 13,8 | 78.4 ± 16.7 | 119.3 ± 20.8 | 127.8 ± 73.6 | 107.7 ± 19.5 | 40–133 |
Uric acid (µmol/l) | 14.0 ± 0.7 | 13.8 ± 0.8 | 13.5 ± 0.8 | 14.5 ± 1.8 | 14.0 ± 0 | – |
Sodium (mmol/l) | 143.8 ± 1.7 | 141.2 ± 1.3 | 141.7 ± 8.3 | 144.0 ± 1.7 | 142.5 ± 2.7 | 140–160 |
Potassium (mmol/l) | 3.7 ± 0.3 | 3.7 ± 0.4 | 3.6 ± 0.7 | 3.9 ± 0.5 | 3.7 ± 0.3 | 4.0–5.0 |
Chloride (mmol/l) | 101.5 ± 2.1 | 99.0 ± 1.4 | 100.0 ± 0.9 | 99.0 ± 2.4 | 101.5 ± 0.6 | 102–106 |
Blood count | ||||||
Leucocytes (×103/µl) | 7.2 ± 1.6 | 7.5 ± 2.1 | 7.6 ± 4.7 | 11.9 ± 6.7 | 7.5 ± 4.0 | 7.0–22.0 |
Erythrocytes (×106/µl) | 5.8 ± 0.7 | 5.0 ± 0.9 ↓ | 7.1 ± 2.3 | 4.5 ± 1.1 ↓ | 5.5 ± 0.9 | 5.8–8.0 |
Thrombocytes (×103/µl) | 507.7 ± 93.1 | 699.0 ± 179.9 ↑ | 371.7 ± 171.3 | 819.3 ± 236.8 ↑ | 554.0 ± 142.0 | 175–587 |
Haemoglobin (g/dl) | 11.6 ± 1.1 | 10.5 ± 1.7 | 14.2 ± 4.1 | 9.2 ± 1.9 ↓ | 11.1 ± 0.9 | 10.0–16.0 |
Haematocrit (%) | 32.2 ± 2.3 | 29.1 ± 4.2 ↓ | 39.0 ± 10.9 | 25.8 ± 5.3 ↓ | 30.9 ± 2.5 | 33.0–45.0 |
MCV (fl) | 56.0 ± 6.1 | 58.3 ± 4.7 | 56.2 ± 6.1 | 57.8 ± 6.1 | 56.8 ± 5.6 | 50.0–68.0 |
MCH (pg) | 20.2 ± 2.2 | 20.9 ± 1.8 | 20.5 ± 2.3 | 20.5 ± 2.3 | 20.4 ± 2.2 | 17.0–21.0 |
MCHC (g/dl) | 36.2 ± 0.9 | 35.9 ± 1.0 | 36.4 ± 0.6 | 35.5 ± 0.7 | 36.0 ± 0.6 | 30.0–35.0 |
Differential blood count | ||||||
Unsegmented granulocytes (%) | 5.0 ± 1.9 | 5.8 ± 1.9 | 5.8 ± 3.1 | 5.3 ± 2.2 | 5.2 ± 3.6 | 0–7 |
Segmented granulocytes (%) | 31.5 ± 16.4 | 33.4 ± 11.4 | 33.7 ± 14.3 | 36.2 ± 12.5 | 26.5 ± 18.5 | 10–39 |
Lymphocytes (%) | 54,5 ± 17,6 | 51.2 ± 10.1 | 54.2 ± 15.1 | 43.8 ± 22.7 | 60.5 ± 24.7 | 49–85 |
Monocytes (%) | 8.0 ± 3.5 | 7.6 ± 2.3 | 5.5 ± 1.4 | 7.0 ± 2.6 | 6.7 ± 2.7 | 0–5 |
Eosinophils (%) | 0.7 ± 1.0 | 1.8 ± 0.8 | 0.7 ± 0.8 | 0.7 ± 1.0 | 1.0 ± 0.9 | 0–6 |
Basophils (%) | 0.3 ± 0.5 | 0.2 ± 0.4 | 0.2 ± 0.4 | 0.3 ± 0.5 | 0.2 ± 0.4 | 0–2 |