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Table 2 Blood and renal parameters of Göttingen minipigs

From: Two differentially structured collagen scaffolds for potential urinary bladder augmentation: proof of concept study in a Göttingen minipig model

  OP I After OP I OP II After OP II Termination Norm
Kidney values (serum) 0 weeks 2 weeks 6 weeks 8 weeks 18/22/32 weeks
Total protein (g/dl) 6.4 ± 0.7 5.2 ± 0.5 6.7 ± 0.5 6.1 ± 0.3 6.5 ± 0.7 4.5–8.5
Urea (mmol/l) 2.4. ± 1.1 1.8 ± 0.1 2.2 ± 0.9 3.7 ± 3.7 2.2 ± 0.9 3.3–8.3
Creatinine (µmol/l) 107.5 ± 13,8 78.4 ± 16.7 119.3 ± 20.8 127.8 ± 73.6 107.7 ± 19.5 40–133
Uric acid (µmol/l) 14.0 ± 0.7 13.8 ± 0.8 13.5 ± 0.8 14.5 ± 1.8 14.0 ± 0
Sodium (mmol/l) 143.8 ± 1.7 141.2 ± 1.3 141.7 ± 8.3 144.0 ± 1.7 142.5 ± 2.7 140–160
Potassium (mmol/l) 3.7 ± 0.3 3.7 ± 0.4 3.6 ± 0.7 3.9 ± 0.5 3.7 ± 0.3 4.0–5.0
Chloride (mmol/l) 101.5 ± 2.1 99.0 ± 1.4 100.0 ± 0.9 99.0 ± 2.4 101.5 ± 0.6 102–106
Blood count
Leucocytes (×103/µl) 7.2 ± 1.6 7.5 ± 2.1 7.6 ± 4.7 11.9 ± 6.7 7.5 ± 4.0 7.0–22.0
Erythrocytes (×106/µl) 5.8 ± 0.7 5.0 ± 0.9 ↓ 7.1 ± 2.3 4.5 ± 1.1 ↓ 5.5 ± 0.9 5.8–8.0
Thrombocytes (×103/µl) 507.7 ± 93.1 699.0 ± 179.9 ↑ 371.7 ± 171.3 819.3 ± 236.8 ↑ 554.0 ± 142.0 175–587
Haemoglobin (g/dl) 11.6 ± 1.1 10.5 ± 1.7 14.2 ± 4.1 9.2 ± 1.9 ↓ 11.1 ± 0.9 10.0–16.0
Haematocrit (%) 32.2 ± 2.3 29.1 ± 4.2 ↓ 39.0 ± 10.9 25.8 ± 5.3 ↓ 30.9 ± 2.5 33.0–45.0
MCV (fl) 56.0 ± 6.1 58.3 ± 4.7 56.2 ± 6.1 57.8 ± 6.1 56.8 ± 5.6 50.0–68.0
MCH (pg) 20.2 ± 2.2 20.9 ± 1.8 20.5 ± 2.3 20.5 ± 2.3 20.4 ± 2.2 17.0–21.0
MCHC (g/dl) 36.2 ± 0.9 35.9 ± 1.0 36.4 ± 0.6 35.5 ± 0.7 36.0 ± 0.6 30.0–35.0
Differential blood count
Unsegmented granulocytes (%) 5.0 ± 1.9 5.8 ± 1.9 5.8 ± 3.1 5.3 ± 2.2 5.2 ± 3.6 0–7
Segmented granulocytes (%) 31.5 ± 16.4 33.4 ± 11.4 33.7 ± 14.3 36.2 ± 12.5 26.5 ± 18.5 10–39
Lymphocytes (%) 54,5 ± 17,6 51.2 ± 10.1 54.2 ± 15.1 43.8 ± 22.7 60.5 ± 24.7 49–85
Monocytes (%) 8.0 ± 3.5 7.6 ± 2.3 5.5 ± 1.4 7.0 ± 2.6 6.7 ± 2.7 0–5
Eosinophils (%) 0.7 ± 1.0 1.8 ± 0.8 0.7 ± 0.8 0.7 ± 1.0 1.0 ± 0.9 0–6
Basophils (%) 0.3 ± 0.5 0.2 ± 0.4 0.2 ± 0.4 0.3 ± 0.5 0.2 ± 0.4 0–2
  1. All results are shown as mean ± SD
  2. No significant differences could be examined
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