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Fig. 9 | Journal of Translational Medicine

Fig. 9

From: Two differentially structured collagen scaffolds for potential urinary bladder augmentation: proof of concept study in a Göttingen minipig model

Fig. 9

Histological development of implanted unseeded OptiMaix 3D scaffolds. Six weeks after implantation, the scaffold seems to be still intact. Connective tissue has started to grow inside the open pores (EVG) and also the ingrowth of muscle tissue is occurring (α-SMA). The urothelium has closed the luminal side of the scaffold but is growing scattered and building vesicles inside the pores (PanCK). These processes are advancing until week 32 with building of a more structured bladder wall and a smoother urothelium. Blood vessels (CD34, VEGF) and nerve fibres (S100) too, are evolving during this time span. S scaffold, M muscle, CT connective tissue. Scale bar = 50 µm

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