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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response

Fig. 6

Analysis of RIG-I (encoded by Ddx58 gene) signaling network after mRNA vaccine treatment in humans (MIMIC®) and mice. a RNA generated from MIMIC®-PTE immune cell populations 24 h after modules were treated with the mRNA vaccine. b The mRNA vaccine was injected into mice, and 6 h post administration RNA was isolated from RNALater-preserved skin biopsies. Up-regulated genes are shown in red, solid lines indicate direct interactions, dashed lines indirect effects, arrow heads indicate causality

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