Dose (μg/kg) | 500 | 1000 | 1000 | 1500 | 2000 | 2000 | 2500 |
---|---|---|---|---|---|---|---|
Infusion time/rate | 2 h./const. | 2 h./const. | 1 h./const. | 2 h./const. | 2 h./const. | 2 h./ramp | 2 h./const. |
n Volunteers | 3 | 7 | 3 | 7 | 6 | 3 | 10 |
Volunteers with AE | 1 | 5 | 1 | 2 | 6 | 2 | 7 |
Erythema | 1 | 4 | 7 | ||||
Pruritus | 2 | 1 | 1 | 4 | 2 | ||
Infusion site erythema | 1 | 2 | |||||
Infusion site pruritus | 1 | 1 | |||||
Urticaria | 1 | 1 | |||||
Flushing | 1 | 1 | |||||
Hypoasthesia oral | 2 | ||||||
BP increase | 2 | ||||||
Blood CK increased | 2 | ||||||
Infusion site irritation | 1 | ||||||
Feeling hot | 1 | ||||||
Muscle tightness | 1 | ||||||
Headache | 1 | ||||||
Hypoasthesia | 1 | 1 | |||||
Throat tightness | 1 | ||||||
Bone pain | 1 | ||||||
Vertigo | 1 |