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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers—results of a dose escalation trial

Fig. 4

Mobilization of immature hematopoietic cells: effects of infusion velocity and rate. a, b Inter-individual comparison of CD34+ cell mobilization after infusion of balixafortide over 1 vs. 2 h demonstrates equivalent mobilization kinetics (a) and peak mobilization responses (b). This cohort received only a single course of G-CSF, hence the data shown for G-CSF mobilization with each of the baselines and balixafortide treatments are the same. Symbols represent individual values, the short horizontal bar and whiskers mean ± SEM. n = 3. c, d Comparison of CD34+ cell mobilization after ramped vs. constant rate infusion of balixafortide demonstrates equivalent mobilization kinetics (c) and peak mobilization responses (d). Symbols represent individual values, the short horizontal bar and whiskers mean ± SEM. n = 3

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